HOW MUCH CBD IS CONSIDERED THE RIGHT DOSE?

How much CBD is the Right Dose For Treatment

 Table 1: CBD Dosing Suggestion for Pain Relief

Condition Person Size (2-25lbs) Person Size (26-45lbs) Person Size (46-85lbs) Person Size (86-150lbs) Person Size (151-240lbs) Person Size (241 + lbs.)
Mild Range 4.5mg 6mg 9mg 12mg 18mg 22.5mg
Medium Range 6mg 9mg 12mg 15mg 22.5mg 30mg
Severe Range 9mg 12mg 15mg 18mg 27mg 45mg

 

Just like any other natural plant with a natural remedy and various functions, it is challenging to determine the exact amount of cannabidiol or CBD that a patient requires to treat a symptom. This is presented by Aswin Suri, Chairman of Neuro-Endoceuticals that “natural remedies such as cannabidiol have a distinct effect on everyone. Additionally, there is little scientific data research that discusses the exact dose for CBD treatment”. However, as argued by Aswin Suri, some patients can’t determine the correct dose or amount of CBD that is needed to treat their symptoms and can achieve consistent results by using ONLY quality CBD. According to Butterfield (2016), some of the factors that regulate or influence the amount of CBD that a patient will need include the quality of the cannabidiol itself and the manner in which it affects or reacts with the respective individual.

Other serving examples that have presented in other research include

  • General Health: 2.5-15mg of CBD by mouth daily
  • Chronic pain: 2.5-20 mg CBD by mouth for an average of 30 days
  • Epilepsy: 200-300 mg of CBD by mouth daily for up to 4.5 months
  • Sleep disorders: 40-160 mg CBD by mouth daily
  • Schizophrenia: 40-1,280 mg CBD by mouth daily for up to four weeks
  • Glaucoma: A single CBD dose of 20-40 mg by mouth daily

On the other hand, since hemp oil with CBD is currently not regulated by the FDA; although ancillary components will be in the very near future, CBD is legally sold as a dietary supplement rather than a medicine, the aspects of carrying out scientific research and coming up with official dosage guidelines is something in the very near future. However, Aswin Suri and Michael Membrino, Chairman and President of Neuro-Endoceuticals respectively, present that the existing research on the importance of CBD and its various medical application have suggested helpful information on choosing the right dosage for CBD treatment. Aswin Suri goes on to say, that using guidelines and instructions on the product together with understanding the personal needs will assist in developing or picking the right dosage for CBD treatments.

With the notion that hemp oil with CBD should be packed and sold according to the FDA terms and conditions, this helps the manufactures and processors indicate the nutritional level and guidelines which determines the amount of CBD available in the product. In this case, the fundamental nutrient level has a suggested serving size. However, every hemp oil with CBD is allowed to legally provide this kind of suggestion; yet it is not advisable to quickly follow the recommendation given to consumers. This is because Aswin Suri, Chairman of Neuro-Endoceuticals stresses on the fact that not all suggestions given by the manufacturer on the CBD bottle is a stable dosage for the CBD treatment. Nevertheless, both Aswin Suri and Michael Membrino suggest that the label recommendation provided by authorized CBD manufactures should provide you with an opportunity to work out how much CBD, in milligrams, the products contain. Be that as it may, the concern of how many milligrams one needs to take and how often to take will depend entirely on your given situation.

Separately, according to Project CBD (2016), cannabidiol or CBD is a non-intoxicating component that is originated from medical cannabis with greater therapeutic potential, ranging from neurodegenerative disorder to mental disorders. This has given CBD a buzz among scientists, health professionals, and medical marijuana patients who are using CBD-rich products to treat a broad range of conditions such as chronic pain, cancer, Crohn’s, diabetes, rheumatoid arthritis, PTSD, cardiovascular disease, anxiety, antibiotic-resistant infections, multiple sclerosis, schizophrenia, and many others. Additionally, scientific research carried out in the United States and elsewhere are currently studying the effects of CBD on these medical condition’s and other ailments. In this case, most of the researchers and medical professionals have referred to CBD as a “promiscuous” compound because it confers therapeutic benefits in many different ways while tapping into how we function physiologically and psychologically on a serious level.

Consequently, extensive research that is connected with technological advancement and the greater importance of hemp oil with CBD have shown that CBD has strong anti-oxidant, anti-inflammatory, anti-convulsant, anti-depressant, anti-psychotic, anti-tumor forming, and overprotective qualities. Cannabidiol can change gene expression and remove beta-amyloid plaque which is the hallmark of Alzheimer’s from brain cells. In the above description, the most appropriate delivery system or the right dosage for CBD treatment is the one that provides an optimal dose for the desired duration with little to no side effects. Suggestively, Aswin Suri also notes that the time of onset and the duration of the effects vary depending on the method of the administration. Hemp oil with CBD can be taken orally (as edibles, lozenges, beverages, tinctures, and gel caps), or applied topically. Concentrated cannabis oil extracts can also be heated and inhaled with a vape pen. Inhalation is suitable for treating acute symptoms that require immediate attention; the effects can be felt within a couple minutes and typically last for a couple of hours.

Moreover, most of the CBD brands use “drops” to describe the serving sizes; for instance, one serving is equivalent to 10 drops. Interestingly, most consumers can find some indication on the packaging on what a serving is translated to regarding the milligrams CBD dosage. In this case, as presented in the table below, if one wants to consume a dose of 10 milligrams of CBD, you will find a suggestion on the package indicating that one serving is equal ten drops which is equivalent to 5 milligrams of CBD. In this case, one you will need to consume two serving 20 drops to the get the accurate dosage for CBD treatment you are looking for. It is noteworthy that most of the CBD dosage products settle for the serving size of 10 drops simply because it is simple and easier for consumers to understand to set their dosage.

Answering questions such as, “How much CBD oil should I take?” is hard to answer because every person is different. This goes to say, even if an individual reduces the dosage to a single condition treatment, that right dosage will always vary. However, Aswin Suri, Chairman of Neuro-Endoceutical holds that the effective dosage of CBD treatment will increase the body weight and the condition severity. The table below attempts to provide the right dose for CBD treatment, although it is not scientifically backed.

Recommendation provided on products is commonly referred to as a “starting point” because they only denote what has worked for their users. In this case, Aswin Suri advises that one needs to pay close attention to the feedback or the symptoms that remain after consuming a particular dosage.

Interestingly, there is not a severe danger for overdosing on CBD. Like any other natural existing remedies, adding extra spinach to your diet will mostly make you healthier. Based on the notion that CBD has little side effects, the fundamental threat that the team at Neuro-Endoceuticals has noted, is not to waste money on consuming more CBD than what your body can take in. On the other hand, as presented by Butterfield (2016) an individual’s sensitivity to CBD is a key factor in determining the appropriate ratio and dosage of CBD-rich medicine. Many people enjoy CBD prophylactically even if you are feeling well.

Other factors to consider when picking out the right dose for CBD treatment includes starting with a small size, paying attention to the symptom improvements, and consulting a medical professional. To start with, consuming CBD in small doses will help in determining how CBD reacts with an individual’s body. In this case, it is vital to understand how your body reacts and responds to CBD before increasing the dose. Secondly, paying attention to the serving size will help in being able to determine if you need a higher or lower dosage to match your weight. Finally, consulting a medical cannabidiol professional will allow a  doctor some day to prescribe and inform you how to use CBD and which dose might be beneficial.

Finally, breaking it down the right dose for CBD treatments, the range goes all the way from four milligrams to thirty milligrams per day. Some of the few outliers we have had, is that a user on a daily dose of 45mg is recommended for an acute condition; however, the vast majority of people realized their doses within the ranges provided in Table 1 above. On the other hand, the heaviest dose of CBD treatment is required by larger individuals; especially if they deal with severe conditions. As noted by Aswin Suri, Chairman of Neuro-Endoceuticals, a 200-pound patient with cancer; managing the side effects of chemotherapy, for instance, would likely consume 25-35 milligrams of CBD treatment on a daily basis.

Other serving examples that have presented in other research include

  • General Health: 2.5-15mg of CBD by mouth daily
  • Chronic pain: 2.5-20 mg CBD by mouth for an average of 30 days
  • Epilepsy: 200-300 mg of CBD by mouth daily for up to 4.5 months
  • Sleep disorders: 40-160 mg CBD by mouth daily
  • Schizophrenia: 40-1,280 mg CBD by mouth daily for up to four weeks
  • Glaucoma: A single CBD dose of 20-40 mg by mouth daily

In conclusion, an effective dosage can range from as little as a few milligrams of CBD enriched cannabis oil to a gram or more. Begin with a small dose of enriched CBD oil, especially if you have little or no experience with cannabis. Take a few small doses over the course of the day rather than one big dose. Use the same dose and ratio for several days. Observe the effects and if necessary adjust the rate or amount. Don’t overdo it. Medical Cannabis compounds have biphasic properties, which means that low and high doses of the same substance can produce opposite effects. Small doses of marijuana tend to stimulate; large doses sedate. Conversely, Aswin Suri, Chairman of Neuro-Endoceuticals provides an important note that when you first begin taking CBD, start off by taking the daily basis once in the morning and once at night. This double consumption is said to be useful in the sense that it allows for the CBD to build tolerance in the body.

References:

Project CBD. (2016). CBD USER’S MANUAL: A beginner’s Guide to cannabidiol and Cannabis Therapeutic.

EYE DISORDERS AND GLAUCOMA

In the past centuries, cannabis sativa was used to treat various eye diseases. Among them is Glaucoma that is characterized by abnormal high intraocular pressure (IOP) that can be advanced to blindness is not well diagnosed and treated. This makes glaucoma to be an irreversible blinding eye disease that generates progressive retinal ganglion cell (Cairns, Baldridge, & Kelly, 2016). In their research. They suggest the endocannabinoid system has pulled in a considerable attention as a possible way of treating glaucoma, commonly because of the observed IOP; hence reducing effects seen after administration of the exogenous cannabinoids (Cairns, Baldridge, & Kelly, 2016).
In this case, the presence of the ECS including CB receptors, endocannabinoids like anandamide (AEA) and 2-arachidonoyl-glycerol (2-AG) in the anterior, posterior lobe of the eye and retina signals the CBS receptors. In effect, cannabinoids in the eye will reduce tear production, and regulate the IOP by decreasing it (Cairns, Baldridge, & Kelly, 2016).
Separately, the presence of the CB1 receptors that are expressed in the primary cells of the neural retina. In this case, the hypotensive effect of the cannabinoid on IOP is primarily affected by the presence of CB1 receptor. On the other hand, following the distribution of the endocannabinoids in the retina and considering the functions of the cannabinoids in modulating IOP in neuropsychology, it is quite clear to suggest that cannabis can be used in treating glaucoma.
Additionally, according to the research conducted by Cairns, Baldridge, & Kelly (2016), Δ9-THC and WIN 55,212-2 activate CB1 and CB1, CB1 can lower the IOP attenuated in βAR knockout mice. This can be concluded that CB1 can stamp down the release of the norepinephrine that reduces the IOP. However, CB2 has little effect in regulating and controlling glaucoma in the sense that they are much sparser in activating IOP.

Looking at the long-term treatment of glaucoma, Cairns, Baldridge, & Kelly (2016) argue that cannabinoids can be used in treating glaucoma and that in chronic, topical application 0.5 percent WIN 55,212-2, was identified in the study to be effective in reducing IOP within few weeks. Conversely, it is evident that CB1has positive characteristics to allosteric modulators that have the capacity of stimulating endocannabinoid-mediated CB1 showing that they lack behavioral side effects and suggest possible use in future treatment of glaucoma.

Other than glaucoma, Aswin Suri and his colleagues have indicated that ECS has been used to regulate other eye disorders. For instance, Cannabinoids are argued to guard against retinal neurotoxicity and have powerful anti-inflammatory and degenerative eye disease. Additionally, CB1 receptor agonist stimulates monoamine oxidase on the bovine retina that stamps down the dopamine release. Phytocannabinoids like THC and CBD have shown the potential to reduce the IOP and protect the retinal blood barrier in diabetic, correspondingly. In conclusion, heightening evidence now suggest that the modulation and correlation of ECS may show potential for management and diagnosis of eye diseases and glaucoma.

References
Cairns, E. A., Baldridge, W. H., & Kelly, M. E. M. (2016). The Endocannabinoid System as a Therapeutic Target in Glaucoma. Neural Plasticity, 2016, 9364091. http://doi.org/10.1155/2016/9364091

Dosing Suggestions

                                         Suggested Dosage

CBD dosing is all about the amount you are getting per serving of the remedy you utilize.

The ratio of CBD-to-THC of a particular strain of hemp/cannabis is good to know. But it doesn’t determine how many milligrams of CBD or THC you’re getting per serving. Plant extract, as well as pure CBD crystal is usually mixed in (diluted) with an oil or other “carrying ingredient.”

Different “CBD oil” or “CBD drops” products may also show a percentage of the plant extract infused in the oil. The percentage is good information, but the actual milligrams per serving is the most important to determine the outcome of improved health that you get.

More severe conditions such as cancer, PTSD, mental well-being, Parkinson’s, epilepsy etc. often require much larger doses. Just as valid, some conditions need less CBD for more effective relief. 1/5 tsp. = 1 milliliter. 1/8th teaspoon is about half that amount. Less may be more!

GENERIC SUGGESTED PROGRESSIVE DOSE FOR ANXIETY RELIEF

• Start by taking 10 to 30 mg. of CBD for the first 3 – 5 days during the day. If sleep is a much bigger issue for you, take it closer to bedtime. Many people say their sleep is improved, but notice how YOU feel, with either day or night time administration.

• If you feel much better, stay with that amount. Start low and go slow. This may be plenty for some people, not enough for others, too much for others. If you feel dizzy, high or too energized (some healthy people feel this – but not if you have depression) reduce the dose to just 4-10 drops only. Give it time to develop the full benefit.

• If you still want to feel more relief, take 25 to 50 mg. of CBD once-a-day for the next 3 – 5 days. If you are taking prescription medications or pain relievers, going slow is a good idea.

• If you feel much better, stay with that dose. Give it time and stay as consistent as possible. Don’t rush. Stick with that for another week or two. The experts suggest taking Sunshine Extract 2 hours apart from taking prescription medications.

• After 10 – 15 days, if you still want to feel better, take 25 to 50 mg. in the day and again in the evening (50 to 100 mg. per day) for the next week or two. You can adjust that to taking both doses in the daytime if daily anxiety is a bigger issue for you.

• If increasing your dose finds you feeling worse, reduce the dose. It’s not uncommon for there to be a “bell curve” effect where an optimum level is not a larger dose of CBD.

• After another 15 -30 days, if you still want to feel better, increase to an amount of 100 to 150 mg total per day. Stick with that dose for 2 – 4 weeks. Now it’s up to you. Going up to 250 mg per day may help in more severe cases, and it may not. This is the time to absolutely print out the clinical studies about cannabidiol and consult your doctor. Your doctor may not be interested. We feel the clinical studies are ESSENTIAL, not just important. Hopefully we can use the science to be in-sync with medical professionals.

Here’s a teaspoon-to-milliliter (volume of liquid) conversion. This shows the milligrams (amount of active ingredient) in a 50 mg./per serving example.

• 1/8 teaspoon = 0.62 ml. = 30.5 mg (milligram) dose of CBD in a 50 mg. per serving product.
• 1/5th teaspoon = 1 ml. = 50 mg. of CBD
• 1/4 teaspoon (1.23 ml.) = 61.5 mg. of CBD.
• 1/3 teaspoon (1.64 ml.) = 82 mg. of CBD.
* 1/2 teaspoon (2.46 ml.) = 125 mg. of CBD
• 1 teaspoon (5 ml) = 250 mg. of CBD when using a 50 mg./serving product.

Here are the doses that experts suggest for ADULTS, CANCER, and PEDIATRICS. For mental wellbeing, we’re focused on Dr. Daniele Piomelli’s study as a proven basis for success.

Everyone is an individual, so observe the results. Never suddenly reduce or increase any prescription medications, especially any SSRI (antidepressant) medications. Add-in a CBD remedy to your wellness routine. Cannabidiol’s benefits increase over a longer period of time.

The CBD Oil Review website suggests using everything from 2 – 1200 mg per day for DIFFERENT treatments. Plus there are a variety of CBD products available – both hemp and marijuana provide the same cannabidiol molecule, but it is critical to know the CBD-to-THC ratio (20:1 or greater) in any product. Find the smokable, tincture, oral/dermal sprays, lozenges etc. treatment that’s best for you.

CBD is clinically shown to be safe, and the claims made on this site are not evaluated by the FDA (because the antiquated U.S. Schedule I legal statutes prevent greater amounts of research). We only share examples and information, not medically perfected advice. It’s often smarter to “start low and go slow” when administering any dietary supplement.

CBD remedies extracted from hemp that contains only 0.3% THC are legal in the U.S. We absolutely do not advise or suggest obtaining any substances that are illegal in your local region.

CBD MAY HELP CREATE NEURONS, NEUROGENESIS

Neurogenesis Gives Birth To New Neurons In the Brain, Helps Relieve Stress
Research Suggests CBD’s Anxiety Relief Is Due To Neurogenesis
Neurogenesis is responsible for creating new neurons within the brain. These neurons process and carry information to the necessary destinations in the body, improving overall function. For some time, neurogenesis was believed to be limited to childhood, but evidence now shows that the brain’s production of new neurons continues well into adulthood.
A study published in The International Journal of Neuropsychopharmacology points to cannabidiol (CBD) as a therapeutically promising component on mental health ailments such as psychosis, anxiety and depression. Researchers studied the potential involvement of hippocampal neurogenesis and CBD in combating anxiety. The findings of the study are promising.
There Are Many Benefits To The Process Of Neurogenesis
The production of new neurons in adulthood shows to correlate with depression. A number of antidepressants attribute their success to stimulating the process of neurogenesis. Furthermore, multiple studies have linked neurogenesis to levels of stress. Stress-relieving activities, such as exercising, have been found to increase the rate of neuron production. Animal observations have shown that this production decreases when under stress.
CBD May Help Create Neurons, Relieve Stress.
While researchers are still learning about neurogenesis, findings suggest that it could help regulate stress levels. Cannabis strains with high levels of CBD are typically known for relieving chronic pain, stress, anxiety, and a number of other conditions. These strains are typically Indica-dominant and some good examples would be: Cannatoni, Ghost Rider, and Frank Ocean.
The medicinal value of CBD has been under intense investigation as of late, but evidence supporting its benefits is being supported more and more every day. In the Neuropsychopharmacology study, a group of researchers from Brazil and Spain aimed to determine the involvement of neurogenesis in the effect of CBD, particularly anxiety relief.
Consistent 30 mg doses of CBD, two hours after a daily stressor, increased neuron production in adult wild mice.
Researchers first caused mice to be stressed. Two hours later, each day, researchers administered to the mice 30 mg of CBD and recorded the levels of neurogenesis. Their findings were that CBD spurred an increase in neuron production and battled the effects of chronic unpredictable stress. The findings of this study demonstrate one of the many benefits that stem from CBD.
Given that most of these uses are associated with brain function, it’s not surprising that CBD is also becoming a popular nootropic, particularly for improving anxiety & well-being.
CBD products are made from CBD-rich cannabis strains. In most cases, these strains contain very low THC levels (0.3% or less), which classifies them as hemp. Unlike medical marijuana, hemp products are legal in all states.

CBD For Addiction & Alcoholism

ALZHEIMER’S DISEASE

Speeding Brain’s Garbage Disposal Could Slow Alzheimer’s

 

In the modern neurodegenerative care, scientists have been on the merge in determining the way of treating diseases associated with the brain. Recent researchers from the role of endocannabinoids to cannabinol have proven the possibility of regulating neurogenesis disorders as asserted by Aswin Suri, Chairman of Neuro-Endoceuticals, USA. On the other hand, recent studies have found that using drugs to boost the activity in the brain “garbage disposal” has the potential of removing the toxic protein that clumps together in the brain to cause Alzheimer’s disease. Consequently, Aswin Suri, Chairman of the Neuro-Endoceuticals and Michael Menbrino, President of Neuro-Endoceuticals, USA, argues that most of the neurological disorder such as AD is characterized by the accumulation of protein in the brain, which will result into various tauopathies.

Research conducted by Feunerburk, Marcellino, and Yue (2010) found that overexpression of protein accumulation in the brain has resulted in various autophagy dysfunction. In their investigation, they discovered that the use of different depressant to boost brain through activation of garbage disposal system slows down the disease in mouse model. However, in the study, the team posted that use of different animals, cellular models, and experimental paradigm may provide distinct differences in conclusions (Feunerburk, Marcellino, and Yue, 2010).

Similarly, research conducted by scientists from the University of Columbia have been reported new ways of activating brain garbage disposal system can reduce the prevalence of Alzheimer’s disease. As reported by Karen Duff, the team leader of the research group, use of drugs to increase or speed up the brain garbage disposal system is beneficial in the sense that it open new interventions for treating the disease and several other neurogenesis disorders (Dockrill, 2015).

Focusing on the nature of protein accumulation in the brain, the cells of the brain tend to clear off the dead cells and replace them with new ones. Because these damaged protein cells may sometimes be sticky, for example, amyloid beta and tau proteins, they clot or stick together and contribute to the development of Alzheimer’s disease. In the study, the team used mouse models and administered rolipram that is an antidepressant to the mice. In their result, they discovered that the level of the toxic protein in the brain of the mice was reduced the positive effect. In their explanation, rolipram activated proteasome and restored the protein disposal to normal levels. Additionally, the drug was associated with the improved memory of the mice, but this was unclear (Dockrill, 2015).

Following the recent study, it was discovered that the mechanism to which rolipram works is through the inhibition of the PDE-4 enzyme, which can increase the activity of proteasome within the brain. On the other end, accumulation of the protein in the brain is connected to reduce peptidase activity, which leads to high levels of ubiquitinated proteins. The potential interference of dysfunctional tau with autophagosome clearance may lead to AD neuropathology. This is possible because tau has have been reported to control the stability or microtubules; hence, the modification of tau can lead to stabilization of the condition. Consequently, it was possible that the researchers were able to activate proteasome, which resulted in the reduction of the tau and improvement in memory function of the mice, it was still on how the anti-depressant worked.

Besides, clinical manifestation shows that rolipram can cause nausea and the drug is not advised to be administered to human beings. In effects, the researchers reported that they have no idea of how the rolipram was able to activate the proteasome and regulated the protein accumulation in the brain. However, it was apparent that the team was able to understand and discover that use of some drugs, in this scenario, rolipram was able to stimulate this disposal system in neurons and efficiently reduces the Alzheimer’s disease.

In this light, there is a potential in new interventions of Alzheimer’s disease and other neurodegenerative illnesses. In conclusion, Aswin Suri, Chairman of the Neuro-Endoceuticals and his colleague Mike Membrino, President of Neuro-Endoceuticals, USA, assert that drugs that may act in activation of proteasome can be used to assist in the management of the AD and other protein based accumulation diseases such as Parkinson’s disease, Huntington’s disease, and frontotemporal dementia.

References Dockrill, P. (2015). Drug that Boost the Brain’s “Garbage Disposal” Slows Alzheimer’s in Mice. Colombia University Medical Care. Funderburk, S. F., Marcellino, B. K., & Yue, Z. (2010). Cell “Self-Eating” (Autophagy) Mechanism in Alzheimer’s Disease. The Mount Sinai Journal of Medicine, New York, 77(1), 59–68. http://doi.org/10.1002/msj.20161

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